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His first real career break arrived at 19 years old, when Timely editor Joe Simon and his creative partner Jack Kirby left the company. Lee was subsequently given the post of interim editor, but it was his talent for writing and imagining epic heroes that earned him the permanent position of editor-in-chief, a seat he would occupy until 1972 when he was made publisher of Timely's later evolution, Marvel Comics.
Lee's truly creative era began in the late 1950s, however, when DC Comics spurred a trend in superhero stories, courtesy of characters like the Flash and the Justice League of America. Lee was given the task of creating a team of heroes similar to JLA for Marvel, the result of which was the Fantastic Four. Working mostly with Kirby as well as with Bill Everett and Steve Ditko, Lee went on to devise personalities like the Hulk, Iron Man, Thor, the X-Men, Daredevil, Doctor Strange and, of course, the Amazing Spider-Man.
In his later career, Lee dabbled in work for DC Comics, refashioning heroes like Superman, Batman, Wonder Woman, Green Lantern and Flash for a series called, "Just Imagine..." His most recent endeavor is a new YouTube channel, aptly named "Stan Lee's World of Heroes."
I'd like to wish Mr. Lee a very happy 90th birthday.